How is Esketamine administered?

Esketamine is administered as a nasal spray. This method of delivery allows for rapid absorption through the mucous membranes of the nasal passages, leading to a quicker onset of action compared to other forms of administration. The intranasal route is particularly beneficial for patients who may have difficulty swallowing pills or those who prefer a method that does not involve needles. This formulation has been specifically developed to help treat certain mental health conditions, such as treatment-resistant depression, effectively and with a user-friendly method of administration.

The other options present methods of medication administration that are not applicable to Esketamine. Oral tablets and topical creams are different forms used for various medications, while injectable medications require a different formulation and delivery method altogether. Thus, the nasal spray option is the correct and most relevant choice for Esketamine.